In home defense scenarios, I prefer a 300AAC Blackout SBR with a short suppressor. 300AAC is an excellent round at 25yards or less. SBR is easy to manipulate around corners, doors and hallways. The suppressor protects your hearing not only for medical reasons but being able to keep your hearing situational awareness if the fight continues after the first engagement.
If I would be required to exit my home and handle a hostile situation outside, I would grab my Benelli M4.